Description:
Overview
Mass Spectrometry (MS) works by converting molecules into ions which can then be detected and analyzed. DESI-MS applications were previously restricted to analyzing solid samples on surfaces. Researchers at Ohio University have discovered a novel application of DESI by fostering the technology to analyze liquid samples. In this technique, titled as liquid sample desorption electrospray ionization mass spectrometry (LS-DESI-MS), liquid samples such as urine are driven to the surface where ionization occurs. In addition, the technology can be modified to provide a platform where ionic reactions occur and could be used with separation techniques such as electrophoresis and micro-fluids for widespread applications.
Commercial Application
The technology can have several beneficial applications in areas of chemical analysis that require a high degree of selectivity. DESI has been highly successful in analyzing a series of samples that may include pharmaceuticals, metabolites, drugs of abuse, explosives, chemical warfare agents and intact tissues. The current extended DESI- MS method has the added advantage of being able to directly analyze liquid samples including urine and blood in pharmaceuticals and forensics applications. The fabrication of a portable device using this technology can facilitate security operations at airports and other security-sensitive areas, especially for monitoring liquid products such as gel, beverages, and perfume. Mass Spectrometers are projected to reach $2.5 billion in earned revenue in 2017. The global Bioinformatics market is projected to grow at an annual growth rate of 21.1% into a $16 billion industry by 2021.
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)
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)
Benefits
• Increase in the scope of the existing technology will be obtained in ionizing bio-fluids in their natural state and by the direct ionization of high mass proteins from solutions.
• Improved response time (in seconds), ionization efficiency and cost effectiveness of the sample analysis by the detection of biological samples without any sample preparation.
• Enhanced effectiveness and sensitivity of the proposed device due to the production of continuous ion signals.
• Enhancement in detection sensitivity of analysis is achieved by spraying a solution of reagents to selectively react with samples.
• Enable high throughput analysis
Development
The new technique was successfully tested by using several types of amino acids, peptides, protein digests and proteins as well as drug-containing urine samples its high sensitivity, selectivity and speed for chemical analysis. Additional research activities may be needed to couple the proposed technique to chromatography, electrophoresis and microfluidics to facilitate high quality of separation in sample analysis. chemical imaging using LS-DESI-MS is another sought after research area. The patent for the proposed technology is pending. Licensing opportunities are available.
Printable Overview
Issued Patents
7,915,579