Treatment of Non-Alcoholic Fatty Liver Disease [ID 14001, 14004, 14025]



Non-alcoholic fatty liver disease (NAFLD) is a disease of excess fat accumulation in the liver of individuals with no history of alcohol abuse which can lead to hepatitis, scarring, cirrhosis, and ultimately hepatic failure resulting in coma or death.  It is the leading cause of liver transplantation and primary liver cancer in the U.S. The prevalence of NAFLD ranges from 10% to 24% in the general population and is associated with obesity, type 2 diabetes, and metabolic syndrome. Fatty liver disease (FLD) is observed in up to 75% of obese people, and 35% of those individuals will progress to NAFLD. Treatment consists of weight loss, fat restricted diet, and lipid lowering medications. Currently there are no treatments that target the progressive hepatic inflammation seen in NAFLD.