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A Novel and Efficacious Therapy for Human Liver Cancer [ID: 18001]

OverviewHuman liver cancer is one of the most pharmacologically challenging cancer types with almost 700,000 (40,710 in the US) new diagnoses and 600,000 (28,920 in US) deaths worldwide, annually. Current approved treatments are limited to surgery (liver transplant, laparoscopy), radiation (brachytherapy), and a single small molecule (sorafenib). ...

Published: 3/8/2024 | Inventor(s): John Kopchick, Vishwajeet Puri, Vishva Sharma, Reetobrata Basu

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Category(s): Life Science > Therapeutics, Pharmaceuticals & Drug Delivery

Therapeutic Peptide for Obesity and Diabetes [ID 17021]

OverviewObesity is a significant public health problem. Statistics show that 70% of U.S. adults are considered overweight or obese and 17% of children under the age of 19 have obesity1. Being overweight or obese puts a person at risk for many other health problems, including heart disease, type 2 diabetes, and cancer2. As a result, the cost of obesity...

Published: 10/27/2020 | Inventor(s): Vishwajeet Puri, John Kopchick, Vishva Sharma, Noyan Gokce

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Category(s): Life Science > Therapeutics, Pharmaceuticals & Drug Delivery

Treatment of Non-Alcoholic Fatty Liver Disease [ID 14001, 14004, 14025]

OverviewNon-alcoholic fatty liver disease (NAFLD) is a disease of excess fat accumulation in the liver of individuals with no history of alcohol abuse which can lead to hepatitis, scarring, cirrhosis, and ultimately hepatic failure resulting in coma or death. It is the leading cause of liver transplantation and primary liver cancer in the U.S. The...

Published: 8/26/2019 | Inventor(s): Kelly McCall, Frank Schwartz, Douglas Goetz, Ramiro Malgor

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Category(s): Life Science > Therapeutics, Pharmaceuticals & Drug Delivery

Therapeutic Delivery of Nitric Oxide and Carbon Monoxide to Tissue for Accelerated Wound Healing [ID 10001]

OverviewExtensive studies of the vascular system, heart and brain have shown that after a brief period of wound ischemia, there is a massive generation of nitric oxide by two nitric oxide synthases. Shortly thereafter, nitric oxide production is diminished as result of increased superoxide production and subsequently, peroxynitrite and highly reactive...

Published: 10/23/2018 | Inventor(s): Tadeusz Malinski

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Category(s): Life Science > Therapeutics, Pharmaceuticals & Drug Delivery, Life Science > Medical Devices

Basal Glucose Transport Inhibitors as Anti-Cancer Therapeutics [ID 09002]

OverviewResearchers at Ohio University have created a new class of therapeutic compounds targeting basal glucose transport with implications for broad efficacy across multiple cancer types. This group of compounds focuses on the inhibition of basal glucose transport as a strategy for cancer treatment.Cancer cells are known to have up-regulated basal...

Published: 1/4/2024 | Inventor(s): Xiaozhuo Chen, Stephen Bergmeier

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Category(s): Life Science > Therapeutics, Pharmaceuticals & Drug Delivery